A 13-week randomized controlled trial on 143 psoriasis patients showed that oral fumaric acid esters plus topical calcipotriol (a vitamin D analog) outperformed fumaric acid esters alone
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When systemic glutathione levels are supported through supplementation, the livers Phase 2 detoxification capacity may be enhanced, helping it to clear the backlog of mast cell mediators from the bloodstream
All these drugs are present a demonstrated senolytic acitivity in vitro and in vivo (Fig.1) but their efficiency in human still need to be investigated

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