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The World Health Organisation has documented the risks of arsenic and the sources of arsenic exposure (WHO, 2022)

Kojic Acid Visibly brightens and reduces the appearance of spots

In practice, this means: No persistent nausea or vomiting for at least 7 consecutive days at the end of the current phase No ongoing diarrhea or significant GI discomfort that impacts daily functioning You are in week 4 or later at the current dose level (the 4-week minimum is absolute) If any of those conditions are not met at week 4, you are not ready to escalate

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Berkoff, D

Picardi PK, Calegari VC, Prada PO, Moraes JC, Araujo E, Marcondes MC, et al