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Early human trials in people with obesity found that daily AOD9604 was well tolerated and had a safety profile similar to placebo, with no major effects on glucose metabolism or IGF1, though weightloss results were modest and inconsistent

That combination is why clinicians and patients started asking about this class

Drucker had read about the work of endocrinologist John Eng, gastroenterologist Jean-Pierre Raufman and biochemist John Pisano, who had sequenced the proteins in Gila monster (Heloderma suspectum) venom and found two that looked like human GLP-1

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Most oral supplements range from 2501000 mg daily, though some practitioners recommend higher doses or alternative delivery methods for specific conditions

and the consistency of their toxicity-alleviating effects across different chemotherapy drugs remains unclear