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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) GAPDH catalyzes a redox reaction, forming a high energy acyl phosphate compound To set the stage for substrate-level phosphorylation, the aldehyde group of glyceraldehyde-3-phosphate is oxidized to a carboxylic acid and the energy available from the oxidation reaction is used, in part, to trap a phosphate from the cytoplasmic pool as an acyl phosphate

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Similarly, in the sub-acute phase after stroke, IGF-1 levels in HFD mice remained higher compared with those in mice fed a standard diet ( p =0.051), while treatment with semaglutide in combination with BI8271 resulted in levels that were similar to those in mice fed a standard diet (Fig

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Signal transducer and activator of transcription 3 (STAT3), a crucial cytoplasmic transcription factor in the STAT family, consists of 770 amino acids and possesses a complex domain structure, facilitating its diverse roles in cell signaling and gene regulation (Ma et al., 2020)