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PMID: 15375005

Patients receiving sitagliptin with metformin and glimepiride had significant improvements in A1C and FPG compared to patients receiving placebo with metformin and glimepiride (Table 11), with mean reductions from baseline relative to placebo in A1C of -0.9% and in FPG of -21 mg/dL

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This raises concerns about potential conflicts of interest and the need for independent research

These trade-offs will likely inform how clinicians and the FDA approach the final approved dose range