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Mast cell degranulation induced by both immune and nonimmune stimuli is also accompanied by arachidonic acid metabolism as well as by the release of preformed mediators that are stored in the granules

La acumulacin de TMA y TMAO en sangre produce como consecuencia trimetilaminuria, condicin que se caracteriza por un fuerte "olor a pescado" en orina, aliento y transpiracin

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A similar PKA-independent pathway was recently demonstrated in TGR5-mediated insulin release in pancreatic cells (Kumar et al., 2+ triggers fusion of peptide-containing secretory granules with the plasma membrane and stimulates secretion from the cells

Reeves S, Bench C, Howard R

10.1152/ajpregu.2001.281.3.R839 Am