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In KFFs 2024 annual budget survey, 13 states under Medicaid fee-for-service contracts cover GLP-1s for obesity treatment, and most require prior authorization for prescription approval

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In diabetes, hyperglycaemia often inhibits the defensive machinery [28, 54] accompanied by increased lipid peroxidation and reduced endogenous antioxidant levels in diabetic patients compared to controls [55, 56]

Domestic drugs Mazdutide and Ecnoglutide exhibit high rates of gastrointestinal toxicities like nausea and vomiting, but their overall AE rates are not much higher than placebo, and they keep discontinuation rates particularly well-controlled

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Studies of similar medications show 50-70% of lost weight returns within 12-24 months of discontinuation