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9,12 Additionally, GLP-1RAs activate nitric oxide (NO) synthase expressed in Schlemms canal and the trabecular meshwork, increasing NO production to reduce trabecular meshwork contraction, improving aqueous outflow

Appreciating the triple agonist action helps explain why retatrutide might succeed in people that have done poorly on other therapies

doi: 10.1684/ejd.2019.3691

Science 361 , 842844 (2018)

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