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4 A 2025 mechanistic study using RAMP1/RAMP3 knockout mice demonstrated this dependence directly: cagrilintide activated area postrema neurons and reduced body weight in wild-type animals but had essentially no effect in mice lacking these receptors, pinning its action to the AMY and AMY subtypes in the hindbrain

This indicates that while the N domain alone binds MAX2 weakly, its tethering to the D2 domain is necessary for robust complex stabilisation (Supplementary Fig

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lf any discomfort occurs, discontinue use and consult a doctor