Lancet 375:14471456 Mannucci E, Ognibene A, Cremasco F et al (2001) Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects
It is often well-tolerated in moderate doses but may have a mild laxative effect, which could be problematic for GLP-1 users already experiencing diarrhea or gastrointestinal upset
Bremholm L, Andersen UB, Hornum M, Hilsted L, Veedfald S, Hartmann B, et al
Diabetes Care 43 , 28592869 (2020) P
Eileen Barr, an obesity physician in East Setauket
Concomitant with the spread of the western lifestyle, the prevalence of these diseases has rapidly increased ( During the past years, the intestine and in particular, intestinal epithelial cells (IEC) are more and more recognized as key players in maintaining metabolic and immune homeostasis