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Using the Connectivity Map, we identified GHK as a compound that can reverse the gene-expression signature associated with emphysematous destruction and induce expression patterns consistent with TGF pathway activation

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Post-mortem tissue and plasma collection At the completion of behavioral testing, all rats were deeply anesthetized with a cocktail of ketamine (90 mg/kg), xylazine (2.7 mg/kg) and acepromazine (0.64 mg/kg) and decapitated

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