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There is an urgent need for additional effective medicines, as the median survival rate is barely 35 years following diagnosis

Cell Metab 25(1):152165

TFEB, a member of the MiT/TFE family, has been found to directly bind with the CLEAR element and further promote lysosomal renewal 92

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GLP-1 agonists are one of a few classes of diabetes medications proven to have cardiovascular, renal and mortality benefit in large-scale prospective randomised controlled trials