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From a mechanistic standpoint, both compounds activate the same GLP-1 and GIP receptors, which means concurrent administration would likely result in receptor saturation at those pathways without proportional additive benefit

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6.1 Recent clinical trials targeting RCD pathways in melanoma and emerging evidence Recent advances in clinical research have witnessed the initiation of multiple trials evaluating RCD-targeted therapies in melanoma, providing preliminary evidence for their safety, efficacy, and predictive biomarkers