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La mayora de los pacientes con hiperpigmentacin de origen racial, o en casos de Sndrome de Peutz-Jeghers, u otras condiciones en que aumenta la melanina solamente demuestran aumento del pigmento en estrato basal, como se observa en estas microfotografas en que puede discutirse un leve aumento de melanocitos y se observa el incremento de melanina en estrato basal