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Prog Mol Biol Transl Sci 121: 23-65, 2014

No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern

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Those using oral contraceptives should use a non-oral or backup method for 4 weeks after starting Zepbound and for 4 weeks after each dose increase

High doses of Vitamin C taken within 1 hour of the shot may lower B12 in blood (minor, stagger doses)

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