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Maintenance dosing schedules are less often than the first doses, usually monthly

Then animals were transferred to RNAi plates for life span experiments

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instead, the goal shifts to preventing excessive weight gain while ensuring adequate nutrition for fetal development

The amounts of total reduced and oxidized glutathione were quantified using a modified Tietze method by Adams ( Safety Measurements Any adverse event during the course of the study was monitored and reported to the study staff at week 6 (visit 5) or week 12 (visit 8) in the clinic or directly to the principal investigator throughout the study