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Of note, TZP produced promotility effect comparable to metoclopramide, which administered p.o

3.2 Lipid accumulation Lipid accumulation is a common feature in the tubular cells of patients with DKD ( Lipotoxicity in renal TECs is associated with inflammation, oxidative stress, mitochondrial dysfunction and cell death ( Hypercholesterolemia also results in lipid deposition in kidney tissue, further compromising oxygen delivery through diffusion ( 3.3 Hypoxia Renal hypoxia has been observed in animal models of diabetes ( The enormous oxygen consumption in the kidneys is largely due to tubular reabsorption

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FEBS Lett 382:213217 Dixon DP, Hawkins T, Hussey PJ, Edwards R (2009) Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily

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The glutathione-bound toxic substance can then be excreted in the urine, sweat, or feces.[ref] Glutathione S-transferase (GSTM1, GSTP1, etc) detoxification reactions Related article : GST Genetic Variants What depletes your glutathione levels