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A recent classification introduces the terms transfusion-dependent thalassemia (TDT) and non-transfusion dependent thalassemia (NTDT) to describe the frequency of blood transfusions, with TDT requiring frequent transfusions and NTDT requiring fewer
In this study, we found that statin-induced cell death in YR1.7 and MC38 exhibited key hallmarks of ferroptosis, including downregulation of GPX4 and could be rescued by ferroptosis inhibitors (ferrostatin-1 and liproxstatin-1) for the majority of lipophilic statins
This approach allows for the functional characterization of key genes and the exploration of their therapeutic potential
Acknowledgements The authors would like to thank Henrik Kim Nielsen, Jens Heisterberg, and Karen Hauda (Novo Nordisk A/S, Denmark), and Gina MacNeil (Novo Nordisk Inc, United States) for review of, and input to, the manuscript, as well as Tina stergaard, Sisse Lakner Schmidt, and Michala Cronberg (Novo Nordisk A/S, Denmark) for help with physical stability analyses
