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The STEP 1 trial ( New England Journal of Medicine , 2021) found that once-weekly subcutaneous semaglutide 2.4 mg (Wegovy) produced an average body weight reduction of approximately 14.9% over 68 weeks in adults with obesity, compared with 2.4% with placebo

This decrease was observed greatest among those on higher doses, where virtually all high-dose patients reached the top of these values

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Improving Insulin Sensitivity In addition to appetite control, Semaglutide also improves insulin sensitivity

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