This evolving evidence base suggests a potential paradigm shift in the management of OSA, where pharmacotherapy could play a central role alongside established device therapies
In the meantime, we can use powerful tools to risk-stratify who attains access to these medications, starting with "sicker" patients
314, Oct
These are not hypothetical concerns
Travel Coolers for Injectables or Vials of GLP-1s I've put a trio of travel coolers that I've tried for my Zepbound vials
Dietary modifications that help: Eat smaller, more frequent meals instead of large ones Prioritize protein-forward meals, as protein is easier to digest when gastric emptying is slowed Avoid high-fat meals, which take longer to digest and can worsen nausea Eat slowly and stop before you feel full, as the sensation of fullness hits faster on retatrutide Stay hydrated with slow, steady sipping rather than drinking large amounts at once Timing strategies: Take your weekly injection at a consistent time each week Many researchers prefer evening injections so that the peak nausea period occurs during sleep Plan your dose increase days on weekends or rest days when GI symptoms are less disruptive Stay upright for at least 30 minutes after eating, as gravity helps with digestion when gastric emptying is slowed Natural remedies for mild nausea: Ginger has demonstrated anti-nausea properties in multiple studies and can help manage mild GI symptoms during dose transitions
