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* Correspondence: Yan Chen, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Heterogeneity of treatment effect is the nonrandom variability in treatment effects for patients within a population

70,71 Additionally, the exploration of GLP-1R positive allosteric modulators (PAMs) offers a new regulatory approach that could enhance the therapeutic profile of small-molecule GLP-1R agonists

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However, individual tolerability and safety to GLP-1RA may vary due to differences in molecular structures ( This review has two main strengths