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For this reason, GLP-1 RAs have become first choice drugs in the subject of diabetes with evidence of atherosclerotic disease and/or previous cardiovascular event [13]

However, oral formulations require strict fasting protocols and may cause more gastrointestinal side effects in some patients

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Patients beginning with a low dose (0.25 mg) progress more slowly than those reaching therapeutic doses (1.0 mg or 2.4 mg) because appetite suppression intensifies with each dose increase