We believe Semaglutide GLP-1 could potentially be a beneficial addition to our arsenal of weight-loss tools
The correct dose, dose escalation schedule and safety monitoring requirements may change if retatrutide is approved in the future
This trend is driving broader prescribing practices beyond endocrinology into primary and cardiovascular care
It activates three receptors simultaneously: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon
Diabetes 68(6):11211129 Grespan E, Giorgino T, Natali A, Ferrannini E, Mari A (2021) Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes
This means the caloric deficit that produced rapid weight loss in the early months narrows as you get lighter, even if your eating habits remain exactly the same