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Orlistat is the most modest of the approved options in terms of weight loss

Even for patients who have successfully lost weight on GLP-1 medications but then regain some of it after discontinuation, bariatric surgery may be an option to consider, especially if their BMI is back in the obese range

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It clearly shares some but not all of the biological effects of intact hGH, with its activity appearing to converge on 3-adrenergic receptor-mediated pathways in adipose tissue rather than through the classical GH receptor

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