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However, tumor cells typically possess an aberrant methylation pattern associated with altered gene expression profiles, showing locally restricted hypermethylation of individual promoter regions involved in the silencing of TSGs

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73 This was a multicentre observational cohort study from 170 hospitals across the US that investigated the effects of GLP-1 RAs on clinical outcomes, a composite of HF hospitalisation and all-cause mortality, in 1,024 obese HFpEF patients compared with 796 controls receiving dipeptidyl peptidase inhibitor/sulphonylurea therapy

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