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High levels of NO, such as those produced by macrophages, can negatively influence fertility in several ways

As the key component in the placenta, trophoblast cells play vital roles in embryo implantation and healthy pregnancy 5,6 Trophoblast cell dysfunctions may induce miscarriage 7

Mice with signs of unrelated illness, abnormal baseline renal function, or technical failure during surgery/crystal injection were excluded from analysis

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