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trial, subjects receiving weekly doses of 30 to 60 mcg/kg (roughly 2,000 to 4,000 mcg for an 80 kg adult) showed sustained IGF-1 elevation with no serious adverse events over the study period (Teichman et al., J Clin Endocrinol Metab 2006)

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The experimental animal feed for the iron overload mouse model (Table S1) was synthesized by Jiangsu Medicience Biological Medicine Co., Ltd (Jiangsu, China)

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