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For patients with advanced metabolic dysfunction, fatty liver disease, or those seeking maximal weight loss, retatrutide may become the gold standard therapy offering results previously only attainable through surgery

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Autophagy is activated after acute injury but decreases in the chronic course and may be associated with disease progression

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Compared to a diet designed for diabetes management, the Palaeolithic diet, also known as the caveman diet, significantly decreased the average HbA1c, triglyceride, diastolic blood pressure, weight, body mass index, and waist circumference [9]