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Published studies describe a range of dosing conditions depending on the model and research goals

Mice were housed under 12-h/12-h light/dark cycle, humidity 5060% and 1822 C ambient temperature with free access to food (chow diet, MD17121, Mediscience Ltd, China) and water

In a randomised controlled trial with over 1800 participants comparing tirzepatide to semaglutide, the tirzepatide group reported more serious adverse events (5-7% VS 3%) and higher discontinuation rates due to adverse events (6-8.5% VS 4%)

Some patients continue to ask for more medication or higher doses despite getting down to BMIs of 20 and 21, which are considered the low end of the normal range

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