For example, in neurodegenerative diseases, infections and other diseases, physiological levels of mitophagy can protect cells from pathogenic factors, but long-term uncontrolled mitochondrial quality control can exacerbate disease-related damage
Within this process, First-in-Human (FIH) trials represent one of the most important transitions in the development of a new medicine
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J Gerontol A Biol Sci Med Sci 65:712717 Li Y, Ma QG, Zhao LH, Guo YQ, Duan GX, Zhang JY, Ji C (2014a) Protective efficacy of alpha-lipoic acid against aflatoxinb1-induced oxidative damage in the liver
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doi: 10.1016/s0003-9861(03)00199-1