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We lack knowledge of the correlation between migration and invasion in RCC, thus few therapeutic options are available (Meng et al., 2015)

Our previous calculations of complete and modeled structures suggest these modifications do not affect the results: Our earlier studies showed that all biochemical processes dependent on vitamin B12 forms occur without energy barriers, consistent with experimental data [2]

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Funding This study was supported by the grants from the Zhejiang Provincial Natural Science Foundation of China (LY22H090001), Medicine and health science and technology projects of Zhejiang province (2022KY305, 2022KY322), Ningbo medical and health brand discipline (PPXK 2018-04) and Ningbo Science and Technology Innovation 2025 Major Project (2022Z134), Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province (2022E10026)

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