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Conclusion GLP-1RAs represent a potential paradigm shift in ophthalmology, offering a move from treating downstream pathology to modifying underlying disease processes through metabolic, anti-inflammatory, and neuroprotective mechanisms

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This precursor peptide consists of a signal peptide, a glucagon-related polypeptide, glucagon, and GLP-1 and GLP-2

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Retatrutide simultaneously activates GIP, GLP-1 and glucagon receptors, a triple-agonist pharmacological profile that has dominated late-stage metabolic research

Phase 2 trial dosing used once-weekly subcutaneous injections with gradual escalation from 1 mg up to 12 mg to minimise gastrointestinal side effects