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Why are GLP-1 medications still not recommended during breastfeeding

The supplemental peptide adds to existing production rather than replacing depleted stores

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They suppress appetite through hypothalamic signaling, enhance insulin sensitivity, reduce glucagon secretion, and slow gastric emptying

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Efficacy of GLP-1 receptor agonists in patients with heart failure and mildly reduced or preserved ejection fraction: a systematic review and meta-analysis