& Horowitz, M
INS-1(832/13) cells were cultured in RPMI-1640 medium supplemented with 10 mM HEPES, 10% heat-inactivated FBS, 2 mM L-glutamine, 1 mM sodium pyruvate, 0.05 mM -mercaptoethanol, 100 iU/ml penicillin, and 100 g/ml streptomycin at 37 C in a humidified 5% CO 2 atmosphere
Mol Endocrinol (1999) 13(12):201324
In contrast to generic medicines which are exact copies of chemically synthesised branded drugs, biosimilars closely resemble the structure and function of their reference product and are produced in modified living organisms like yeast and bacteria
Furthermore, those who died during followup could have been misclassified, that is, as nonadherent
The growing recognition of obesity as a chronic disease requiring sustained intervention will drive demand for structured treatment pathways and outcomes-based reimbursement arrangements