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Topical application has been the most commonly studied route in skin and wound research, while subcutaneous administration appears in systemic studies

Among these, nanoparticles (20 - 200 nm) stand out for their enhanced solubility and targeted delivery capabilities, though they face challenges such as potential toxicity and clearance by the mononuclear phagocyte system (MPS) (7)

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As the next phase of this research, more sophisticated in vivo models, incorporating chronic injury paradigms, long-term follow-ups, and genetic or pharmacological modifications of inflammatory pathways, will be critical to substantiate the translational potential of this approach

MT-II is sensitive to light degradation keep vials in a dark environment when not in use and minimize exposure during handling

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