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Several mechanisms have been reported for the increased activity of NRF2 in cancers ( Figure 5 ): (1) somatic mutations in KEAP1 or NRF2 , (2) DNA hypermethylation at the promoter region of KEAP1 , (3) the aberrant accumulation of proteins that disrupt the KEAP1NRF2 interaction, (4) transcriptional up-regulation of NRF2 gene through oncogene-dependent signaling, and (5) the modification of KEAP1 protein through oncometabolites

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The resulting plasmid was linearised by AflII digestion (NEB) and transformed into PichiaPink Strain one (Invitrogen, USA) by electroporation

[51] Human synovial sarcoma cells exposed to RA in vitro were found to have enhanced response to doxorubicin, vincristine, and especially cisplatin

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This lightweight, highly effective treatment fortifies skin with essential nutrients and provides a smoother, firmer and more vibrant looking complexion