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A few reports do show T cell line or clone cytotoxicity toward isologous thyroid epithelial cells, and experimental thyroiditis can be transferred by lymphocytes

Its role in skin brightening comes from a specific mechanism: it inhibits tyrosinase

Recently it has become apparent that immune dysregulation rather than an overactive immune response per se can play a significant role in disease pathology

Dosing protocols are entirely experimental

Mechanistically, TSA treatment increases the transcription levels of transcription factor EB (TFEB) and its downstream autophagy-lysosome pathway-related genes, including cystinosin and hermansky-pudlak syndrome 1

Similarly, bile acid treatment rescued microbial diversity and restored 5-HT, DA, acetylcholine, BDNF, and tropomyosin receptor kinase B levels in both brain and gut of zebrafish, alleviating behavioral symptoms (Qian et al., 2025)