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The efficacy of interventions for TBI is challenged by factors such as TBIs heterogeneity and the variability in brain states and structures

2,3 Furthermore, several cardiovascular outcome trials (CVOT) suggest GLP-1 RAs confer a mortality benefit, with significant reductions in major adverse cardiovascular events, all-cause mortality, heart failure severity, and worsening kidney function

Sample population sizes varied across the 9 studies, ranging between 9 and 45 participants

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to reconcile the genetics and observational estimates additional longitudinal and experimental studies are needed

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