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BPC-157 interacts with the nitric oxide (NO) system, which regulates vascular tone and neural signaling (Sikiri et al., J Pharmacol Sci, 2014)

Open-loop task Mice were injected subcutaneously with tesofensine (2 mg/kg, 6 mg/kg, or saline) and maintained in their homecage for 30 minutes

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The authors suggest an implication of the phosphorylated CREB, mediated by PI-3K and MAPK signaling pathways, that is known to decrease neurotoxicity and oxidative stress-induced neuronal death (Riccio et al., 1999