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For example, a 2024 paper in Anesthesiology noted: Is there any evidence that the risk of gastroparesis or gastric contents is altered by holding the daily or weekly dose

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In clinical trials examining GLP-1 RA in combination with a sulphonylurea (with or without metformin) or insulin, the incidence of hypoglycemia was low overall, but increased when compared with placebo [114]

Another practical observation is that many people regain weight once the medication is stopped, suggesting the underlying metabolic drivers may not have been fully addressed

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