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The deepest irony at the heart of the peptide boom is that the people injecting these compounds are often doing so in the name of taking science seriously, essentially acting on emerging knowledge before the mainstream catches up

His patients werent just losing weight, but fatand a particular kind of fat

An interim analysis was planned after two thirds of the total events had accrued with clear stopping rules and an alpha spending function to account for this interim look (in fact, the interim analysis did not take place until 741 events, out of the planned 854, took place)

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