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However, semaglutide's slower start yields faster total weight loss by week 8because it sustains efficacy without toleranceand produces 2 to 3 times greater cumulative weight loss over 12 months

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A key outcome is the formation of platelet-leukocyte aggregates (PLAs), which exacerbate thromboinflammation and endothelial dysfunction

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Two short-term studies were performed at the FDAs request

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