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The leptin receptor is activated by leptin binding, which occurs when fat cells become larger, indicating adequate or excessive body fat stores

Contraindicated in cardiovascular disease, glaucoma, hyperthyroidism, pregnancy, breastfeeding, and children under 16

[DOI] [PMC free article] [PubMed] [Google Scholar] Seeley RJ, Blake K, Rushing PA, Benoit S, Eng J, Woods SC, DAlessio D, 2000

Wegovy, like Ozempic, uses the GLP-1 receptor agonist semaglutide

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Vomiting is a reported side effect of Mounjaro, although its less common than nausea, with less than 1 in 10 (approximately 9%) of users reporting this side effect