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We also found genetically predicted higher acetyl-carnitine was associated with lower HDL-cholesterol in men and possibly also in women (Additional file 2: Fig

L-Carnitine, and particularly its ability to cross into neural tissues, supports the synthesis of acetylcholine, a critical neurotransmitter for the vagus nerve

It modulates nitric oxide pathways to normalize lower esophageal sphincter function, reduces oxidative stress markers like malondialdehyde, and decreases inflammatory cytokine expression (TNF-, IL-6)

Examples include hypertension, heart disease, and diabetes

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The pcDNA3.1(+)-GSTA2X was used as a template to amplify the cDNA fragment encoding GSTA2X protein