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[DOI] [PMC free article] [PubMed] [Google Scholar] Schoellnast H, Deutschmann HA, Hermann J, Schaffler GJ, Reittner P, Kammerhuber F, Szolar DH, Preidler KW

For active B12 deficiency, most clinicians recommend weekly or biweekly shots for the first 4 to 6 weeks, then a maintenance shot every 1 to 3 months

While all approved sites (abdomen, upper arm, thigh, buttock) are effective, some studies show slightly better absorption from the abdomen

It can also help to ask a provider how they evaluate research involving compounds that have not yet completed full regulatory review, since this shapes how cautiously they approach any specific figure

These include nausea, vomiting, diarrhoea, and constipation, most of which were mild to moderate in severity and occurred most frequently during dose escalation [8]

Initial weight loss typically appears between days 10 and 21 as your calorie intake naturally decreases