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In addition to KEAP1, other forms of regulatory proteins of NRF-2 have recently been discovered, such as the E3-Ubiquitin-ligase adaptor, and the -transducin repeats-containing protein (-TrCP), which can also be degraded by Glycogen Synthase Kinase 3 (GSK-3), phosphorylizing NRF-2 into its residue as serine in the Neh 6 domain, corresponding to the recognition of -TrCP [18] (Fig

they also did not fully control for dietary habits, medication use, age, or geographic differences, all of which can markedly influence microbiota compositio

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DOI: 10.1016/j.bbadis.2012.09.007 23

Neurology, 41 (11), 17261732