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Nonetheless, for new GLP-1 drugs in development, it is imperative to evaluate potential drug interactions since this drug class can alter the efficacy of concomitant medications or increase the risk of adverse events as a result of higher exposure to a co-administrated drug

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Statistics Statistical comparisons were performed with simple main effect test, or ANOVA with Bonferroni/GamesHowell post-hoc tests, as appropriate

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The risk of HHF was significantly reduced for both semaglutide and tirzepatide, with increased specific-disease QoL questionnaire (Kansas City Cardiomyopathy Questionnaire (KCCQ)) scores and performance on the 6-minute walking test