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2024;25:58 Liu H, Drew P, Gaugler AC, Cheng Y, Visner GA

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For skin, the primary mechanisms include stimulation of collagen I and III synthesis, increased production of decorin (which organizes collagen fibers), upregulation of VEGF for blood vessel formation, and activation of tissue remodeling through metalloproteinase regulation

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However, achieving and maintaining this degree of weight reduction through lifestyle modification alone is challenging for most patients, creating an urgent need for effective pharmacological therapies

If symptoms remain significant and the patient wants to continue semaglutide, dietary modification of high-sulfur foods should accompany medication