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Scand J Gastroenterol 2004: 36

Hepatic Steatosis : Recently, a sub-study of the phase 3 clinical trial SURPASS-3 showed that, among patients receiving metformin and/or SGLT2 inhibitors, the addition of tirzepatide (10 or 15 mg) as compared to insulin degludec was able to significantly reduce hepatic fat content (evaluated by magnetic resonance) after 52 weeks of treatment

It may be useful in patients who have achieved their goal weight and are using lower doses to maintain their weight. However, early data and clinical experience suggest that it is an effective strategy, Orandi commented

The two main manufacturers for GLP-1s, Novo and Lilly, both provide DTC options that can make the meds more affordable to patients who can't use their insurance for them

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Fructose Consumption : Foods high in fructose, such as those containing high fructose corn syrup, can alter leptin function and promote weight gain and resistance