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Scientists have also identified copper as a regulator of phosphodiesterase 3 (PDE3), an enzyme involved in fat metabolism

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Biochem Biophys Res Commun 468(12):365371

Interestingly, only one case of Reyes syndrome associated with Kawasaki disease has ever been reported, and only in the Japanese literature, giving an incidence of 0.005%

Upon activation, microglia upregulate NADPH oxidase 2 which produces superoxide and inducible nitric oxide synthase, ultimately generating nitric oxide